Switching the mode of sucrose utilization by Saccharomyces cerevisiae

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Switching the mode of sucrose utilization by Saccharomyces cerevisiae

BACKGROUND Overflow metabolism is an undesirable characteristic of aerobic cultures of Saccharomyces cerevisiae during biomass-directed processes. It results from elevated sugar consumption rates that cause a high substrate conversion to ethanol and other bi-products, severely affecting cell physiology, bioprocess performance, and biomass yields. Fed-batch culture, where sucrose consumption rat...

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Switching the mode of metabolism in the yeast Saccharomyces cerevisiae.

The biochemistry of most metabolic pathways is conserved from bacteria to humans, although the control mechanisms are adapted to the needs of each cell type. Oxygen depletion commonly controls the switch from respiration to fermentation. However, Saccharomyces cerevisiae also controls that switch in response to the external glucose level. We have generated an S. cerevisiae strain in which gluco...

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ژورنال

عنوان ژورنال: Microbial Cell Factories

سال: 2008

ISSN: 1475-2859

DOI: 10.1186/1475-2859-7-4